Reformulación de un gel a base de capsicum annuum con efecto reductor del fibroedema geloide mucoso subcutáneo, mediante la adición de un coadyuvante que aumente su liberación in vitro.
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Date
2025
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Publisher
Universidad de Concepción
Abstract
El fibroedema geloide mucoso subcutáneo (FGMS), comúnmente conocido como celulitis, es una condición de la piel de alta prevalencia para la cual no existen tratamientos definitivos. En este estudio se reformuló un gel tópico a base de Capsicum annuum, con efecto reductor del FGMS, mediante la incorporación de coadyuvantes (Transcutol® y Lecigel®) que mejoran la liberación in vitro de capsaicina, su principal compuesto bioactivo. Se evaluaron distintas proporciones de estos excipientes, seleccionando aquellas que demostraron mayor eficacia en la liberación del principio activo sin comprometer la estabilidad ni la viabilidad celular. La formulación con Transcutol® al 15 % p/p mostró una mayor cesión de capsaicina, y ambas formulaciones fueron fisicoquimicamente estables durante un periodo de 90 días, sin evidencia. de citotoxicidad. Este estudio aporta una base tecnológica sólida para el desarrollo de productos cosméticos innovadores enfocados en el tratamiento del FGMS. Se recomienda validar estas formulaciones en estudios clínicos y explorar su aplicación con otros principios activos lipofílicos.
Fibroedema geloide mucoso subcutáneo (FGMS), commonly known as cellulite, is a highly prevalent aesthetic condition for which no definitive treatment exists. This study focused on reformulating a topical gel based on Capsicum annuum, aimed at reducing FGMS, through the incorporation of absorption enhancers (Transcutol® and Lecigel®) to improve the in vitro release of capsaicin, its main bioactive compound. Various concentrations of these excipients were evaluated, selecting those that demonstrated the greatest efficacy in drug release without compromising stability or cellular viability. The formulation containing 15% p/p Transcutol® exhibited optimal drug release while maintaining stable physicochemical properties and no evidence of cytotoxicity. The findings confirm that the use of transdermal absorption enhancers improves the bioavailability of capsaicin, offering a technologically feasible alternative for the development of dermocosmetic products targeting FGMS. Further clinical validation is recommended, as well as exploration of this strategy with other lipophilic active ingredients.
Fibroedema geloide mucoso subcutáneo (FGMS), commonly known as cellulite, is a highly prevalent aesthetic condition for which no definitive treatment exists. This study focused on reformulating a topical gel based on Capsicum annuum, aimed at reducing FGMS, through the incorporation of absorption enhancers (Transcutol® and Lecigel®) to improve the in vitro release of capsaicin, its main bioactive compound. Various concentrations of these excipients were evaluated, selecting those that demonstrated the greatest efficacy in drug release without compromising stability or cellular viability. The formulation containing 15% p/p Transcutol® exhibited optimal drug release while maintaining stable physicochemical properties and no evidence of cytotoxicity. The findings confirm that the use of transdermal absorption enhancers improves the bioavailability of capsaicin, offering a technologically feasible alternative for the development of dermocosmetic products targeting FGMS. Further clinical validation is recommended, as well as exploration of this strategy with other lipophilic active ingredients.
Description
Tesis presentada para optar al grado de Magíster en Ciencias Farmacéuticas.
Keywords
Celulitis, Cosméticos, Pimentones