Efecto de los principios activos presentes en la planta de Cannabis Sativa sobre la modulación de la respuesta inflamatoria en el sistema Monocito-Macrófago.
Loading...
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad de Concepción
Abstract
Los macrófagos son células del sistema inmunitario que orientan y coordinan procesos en la respuesta inmune innata y adaptativa, sus funciones básicas son la fagocitosis de agentes infecciosos, presentación antigénica y secreción de citoquinas. Estas funciones pueden ser reguladas por el Sistema Endocannabinoide mediante sus receptores, clásicos y no clásicos, y sus ligandos endógenos. Sin embargo, las moléculas presentes en la planta de Cannabis sativa, los fitocannabinoides, flavonoides y terpenos, también actúan como ligandos para el sistema endocannabinoide provocando un efecto celular en el sistema monocito-macrófago que modulan la respuesta inflamatoria y otros aspectos de la respuesta inmune, lo que conlleva a un cambio en el funcionamiento inmunológico. Este es un punto relevante para el estudio de diversas patologías asociadas a procesos inflamatorios y para el entendimiento de los efectos de variedades de Cannabis sativa y/o sus principios activos sobre el sistema inmune. Para sistematizar las funciones que tienen los principios activos de la planta de Cannabis sativa en el sistema monocito-macrófago, se realizó una revisión utilizando bases de datos disponibles por el servicio de Bibliotecas de la Universidad de Concepción. En ella se describieron los determinantes moleculares, el efecto celular y la dosis utilizada de los principios activos. De esta forma se obtuvo una vista global, pero especifica, de la regulación de la respuesta inflamatoria en el sistema monocito-macrófago por parte de moléculas presentes en la planta de Cannabis sativa.
Macrophages are cells of the Immune system that guide and coordinate processes in the innate and adaptive immune response, phagocytosis of infectious agents, antigen presentation and cytokine secretion are some of their basic functions. These functions can be regulated by the Endocannabinoid system through its classical and non-classical receptors and its endogenous ligands. However, in the Cannabis sativa plant, there are molecules that can also act as ligands for the Endocannabinoid system: the phytocannabinoids, flavonoids and terpenes, causing a cellular effect in the monocyte-macrophage system that manages to modulate the inflammatory response and other aspects of the immune response, which leads to a change in immune function. This is a relevant point of view for the study of various pathologies associated with inflammatory processes. To better understand the functions that the actives constituents of the Cannabis sativa plant have in the monocyte-macrophage system, a literature review was conducted using databases available from the library service of the University of Concepción. In the review, the molecular determinants, the cellular effect, and the dose of the active constituents were described. In this way, a global but specific view of the regulation of the inflammatory response in the monocyte-macrophage system by molecules present in the Cannabis sativa plant was obtained.
Macrophages are cells of the Immune system that guide and coordinate processes in the innate and adaptive immune response, phagocytosis of infectious agents, antigen presentation and cytokine secretion are some of their basic functions. These functions can be regulated by the Endocannabinoid system through its classical and non-classical receptors and its endogenous ligands. However, in the Cannabis sativa plant, there are molecules that can also act as ligands for the Endocannabinoid system: the phytocannabinoids, flavonoids and terpenes, causing a cellular effect in the monocyte-macrophage system that manages to modulate the inflammatory response and other aspects of the immune response, which leads to a change in immune function. This is a relevant point of view for the study of various pathologies associated with inflammatory processes. To better understand the functions that the actives constituents of the Cannabis sativa plant have in the monocyte-macrophage system, a literature review was conducted using databases available from the library service of the University of Concepción. In the review, the molecular determinants, the cellular effect, and the dose of the active constituents were described. In this way, a global but specific view of the regulation of the inflammatory response in the monocyte-macrophage system by molecules present in the Cannabis sativa plant was obtained.
Description
Tesis presentada para optar al título de Bioquímico/a.
Keywords
Cannabis, Monocitos, Macrófagos, Antígenos de histocompatibilidad