Ingesta de productos finales de glicación avanzada y su posible efecto sobre el riesgo de desarrollar enfermedad cardiovascular en pacientes con diabetes mellitus tipo 2.
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad de Concepción
Abstract
La dieta moderna occidental contiene altos niveles de productos finales de glicación avanzada (AGEs). Se propone que los AGEs dietéticos podrían actuar en sinergia con los AGEs endógenos producidos durante la diabetes mellitus tipo 2 (DMT2), contribuyendo posiblemente a aumentar el riesgo de desarrollar enfermedad cardiovascular (ECV) en estos pacientes, por lo que el objetivo de esta revisión bibliográfica fue analizar la ingesta de AGEs y su posible efecto sobre el riesgo de desarrollar ECV en pacientes con DMT2. La búsqueda se realizó en: PubMed, Scopus y Biblioteca Virtual en Salud abarcando las publicaciones de los últimos 5 años. Incluyó artículos con pacientes con DMT2, mayores a 18 años y en idioma inglés. Se identificaron 50 artículos, de los cuales solo 19 fueron incluidos en la revisión. Las dietas con alto aporte de AGEs podrían promover la inflamación y estrés oxidativo a través del aumento de marcadores de inflamación, marcadores de daño endotelial y concentraciones séricas de AGEs. Mientras que las dietas con bajo aporte de AGEs han demostrado reducir los niveles séricos de AGEs y con ello el grado de estrés oxidativo, inflamación y disfunción endotelial. En conclusión, la alta ingesta de AGEs contribuiría a aumentar el riesgo de desarrollar ECV en pacientes con DMT2 a expensas, principalmente, del daño endotelial producido por el aumento de los AGE sistémicos
The modern Western diet contains high levels of advanced glycation end products (AGEs). It is proposed that dietary AGEs could act synergistically with endogenous AGEs produced during type 2 diabetes mellitus (T2DM), possibly contributing to an increased risk of developing cardiovascular disease (CVD) in these patients, so the aim of this literature review was to analyze AGEs intake and its possible effect on the risk of developing CVD in patients with T2DM. The search was performed in: PubMed, Scopus and Virtual Health Library covering publications from the last 5 years. It included articles with patients with T2DM, older than 18 years of age and in English. Fifty articles were identified, of which only 19 were included in the review. Diets high in EFAs could promote inflammation and oxidative stress through increased markers of inflammation, markers of endothelial damage and serum concentrations of EFAs. Whereas diets with low EFA intake have been shown to reduce serum EFA levels and thus the degree of oxidative stress, inflammation and endothelial dysfunction. In conclusion, high EFA intake would contribute to increase the risk of developing CVD in patients with T2DM mainly at the expense of endothelial damage produced by the increase in systemic AGEs.
The modern Western diet contains high levels of advanced glycation end products (AGEs). It is proposed that dietary AGEs could act synergistically with endogenous AGEs produced during type 2 diabetes mellitus (T2DM), possibly contributing to an increased risk of developing cardiovascular disease (CVD) in these patients, so the aim of this literature review was to analyze AGEs intake and its possible effect on the risk of developing CVD in patients with T2DM. The search was performed in: PubMed, Scopus and Virtual Health Library covering publications from the last 5 years. It included articles with patients with T2DM, older than 18 years of age and in English. Fifty articles were identified, of which only 19 were included in the review. Diets high in EFAs could promote inflammation and oxidative stress through increased markers of inflammation, markers of endothelial damage and serum concentrations of EFAs. Whereas diets with low EFA intake have been shown to reduce serum EFA levels and thus the degree of oxidative stress, inflammation and endothelial dysfunction. In conclusion, high EFA intake would contribute to increase the risk of developing CVD in patients with T2DM mainly at the expense of endothelial damage produced by the increase in systemic AGEs.
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Keywords
Productos finales de glucosilación avanzada, Enfermedades cardiovasculares, Diabetes mellitus tipo 2, Dieta, Alimentos