Determinación de ocratoxina A en plasma humano y su relación con el consumo de alimentos posiblemente contaminados.
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Date
2005
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad de Concepción.
Abstract
Ochratoxin A is a mycotoxin produced by several Aspergillus species and in less
proportion by Penicillium species. The distribution of Ochratoxin A (OTA) in the
environmental is widely known. It is possible to find it as contaminant of food like cereals
and derivates, wine grapes, meat of pork and chicken and derivates like eggs. Several
studies have demonstrated the presence of OTA in human and animal tissues and foods.
The carcinogenic properties of OTA have contributed to fix maximum limits allowed for
foods and human intake in several countries.
In this work OTA production by three toxicogenic species was studied, using wheat
as matrix. The result obtained can be used to apply adequate plans of food control to
prevent the contamination of food by OTA.
In the second part of this work, the presence of OTA in human plasma was
determinate and it was compared with food consumption through an alimentary
questionnaire.
Finally, the comparison between two methodologies for the determination of
Ochratoxin A in wheat was done. As part of this comparison some wheat samples were
analyzed with the objective to know about the presence of OTA in the Chilean food.
In Chile does not exist information about the presence of this mycotoxin in food and
human tissue, for this reason, this study should be a first approach to the problem calling
for further researches.
Description
Tesis para optar al Grado de Magíster
Keywords
Contaminación de Alimentos, Farmacología, Micotoxinas, Ocratoxinas