Análisis cuantitativo de la organización del tejido embrionario del pez cebra.
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Date
2024
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Universidad de Concepción
Abstract
En esta tesis, se realizó un análisis cuantitativo de la organización del tejido embrionario del pez cebra durante la etapa de desarrollo temprano. Para ello, se emplearon la teoría de los cristales líquidos y herramientas matemáticas avanzadas para estudiar el comportamiento de conjuntos celulares. Se desarrollaron herramientas computacionales que permitieron procesar imágenes, identificar contactos celulares y analizar sus comportamientos mediante la descomposición de modos esféricos. Posteriormente, se caracterizaron estos comportamientos de manera tensorial utilizando la teoría de tensores de textura de la ciencia de materiales. La validez de estos métodos se comprobó mediante geometrías simples y datos artificiales, aplicándolos finalmente a datos reales del articulo Shah, G. et al.« Multi-scale imaging and analysis identify pan-embryo cell dynamics of germlayer formation in zebrafish».
In this thesis, a quantitative analysis of the organization of zebrafish embryonic tissue during the early gastrulation stage was conducted. The theory of liquid crystals and advanced mathematical tools were employed to study the behavior of cellular assemblies. Computational tools were developed to process images, identify cellular contacts, and analyze their behaviors using spherical mode decomposition. Subsequently, these behaviors were characterized tensorially using the fabric tensor tools from materials science. The validity of these methods was verified with simple geometries and artificial data, and finally, the algorithms were applied to real data.
In this thesis, a quantitative analysis of the organization of zebrafish embryonic tissue during the early gastrulation stage was conducted. The theory of liquid crystals and advanced mathematical tools were employed to study the behavior of cellular assemblies. Computational tools were developed to process images, identify cellular contacts, and analyze their behaviors using spherical mode decomposition. Subsequently, these behaviors were characterized tensorially using the fabric tensor tools from materials science. The validity of these methods was verified with simple geometries and artificial data, and finally, the algorithms were applied to real data.
Description
Tesis presentada para optar al grado académico de Magíster en Ciencias con Mención en Física
Keywords
Investigación cuantitativa, Embriología, Modelos matemáticos