Niveles de actividad física y su correlación con ritmo cardíaco, parámetros bioquímicos y memoria.
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Date
2023
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Universidad de Concepción
Abstract
La actividad física (AF) confiere beneficios para la salud ampliamente documentados, especialmente a nivel cardiovascular (CV). Recientemente, se evalúa si AF tendría efectos sobre funciones superiores del sistema nervioso, como cognición y memoria. Exerquinas, como el factor neurotrófico derivado del cerebro (BDNF) que participa en memoria, aprendizaje y plasticidad sináptica, corresponden a moléculas que responden a los niveles de AF. Nuestro objetivo fue evaluar la respuesta a los niveles de AF (pasos) sobre elementos bioquímicos, BDNF y diferentes tipos de memoria (n=36). Se realizaron análisis de correlación lineal a partir del registro de parámetros fisiológicos (AF y CV) utilizando relojes deportivos, medición de variables antropométricas, signos clínicos, determinaciones bioquímicas y de BDNF en suero, aplicación de test cognitivos e instrumento de autoevaluación psicológica DASS-21. Resultados confirman el impacto de AF sobre niveles de BDNF (r=0,89) y frecuencia cardíaca en reposo (r=-0,39), que asimismo mediaría la condición cardiorrespiratoria (eVO2max, r=-0,72). Aunque nuestros datos no sostienen un efecto directo de BDNF en desempeño cognitivo, otros parámetros fisiológicos como fuerza de agarre y bioquímicos como insulina, se asociaron significativamente con memoria secuencial (r=0,85 y r=-0,84). Estos resultados asocian niveles de AF con eVO2max, que impactaría en niveles de BDNF e insulina, constituyendo posibles mecanismos moleculares asociados al desempeño cognitivo.
Physical activity (PA) confers widely documented health benefits, especially at the cardiovascular (CV) level. Recently, it has been evaluated whether PA would have effects on higher functions of the nervous system, such as cognition and memory. Exerkines, such as brain-derived neurotrophic factor (BDNF), which participated in memory, learning and synaptic plasticity, correspond to molecules that respond to PA levels. Our objective was to evaluate the response to PA levels (steps) on biochemical elements, BDNF and different types of memory (n=36). Linear correlation analyzes were carried out from the recording of physiological parameters (PA and CV) using sports watches, measurement of anthropometric variables, clinical signs, biochemical and serum BDNF determinations, application of cognitive tests and psychological self-assessment instrument DASS-21. Results confirm the impact of PA on BDNF levels (r=0,89) and resting heart rate (r=-0,39), which would also mediate cardiorespiratory fitness (eVO2max, r=-0,72). Although our data do not support a direct effect of BDNF in cognitive performance, other physiological parameters, such as grip strength, and biochemical parameters, such as insulin, were significantly associated with sequential memory (r=0,85 and r=-0,84). These results associate PA levels with eVO2max, which would impact BDNF and insulin levels, constituting possible molecular mechanisms associated with cognitive performance.
Physical activity (PA) confers widely documented health benefits, especially at the cardiovascular (CV) level. Recently, it has been evaluated whether PA would have effects on higher functions of the nervous system, such as cognition and memory. Exerkines, such as brain-derived neurotrophic factor (BDNF), which participated in memory, learning and synaptic plasticity, correspond to molecules that respond to PA levels. Our objective was to evaluate the response to PA levels (steps) on biochemical elements, BDNF and different types of memory (n=36). Linear correlation analyzes were carried out from the recording of physiological parameters (PA and CV) using sports watches, measurement of anthropometric variables, clinical signs, biochemical and serum BDNF determinations, application of cognitive tests and psychological self-assessment instrument DASS-21. Results confirm the impact of PA on BDNF levels (r=0,89) and resting heart rate (r=-0,39), which would also mediate cardiorespiratory fitness (eVO2max, r=-0,72). Although our data do not support a direct effect of BDNF in cognitive performance, other physiological parameters, such as grip strength, and biochemical parameters, such as insulin, were significantly associated with sequential memory (r=0,85 and r=-0,84). These results associate PA levels with eVO2max, which would impact BDNF and insulin levels, constituting possible molecular mechanisms associated with cognitive performance.
Description
Tesis presentada para optar al título de Bioquímico/a.
Keywords
Ejercicio Físico, Frecuencia Cardíaca, Memoria, Metabolismo